![]() ![]() Let us know how this access is important for you. tachycardia of 150 bpm should be suspected to be atrial flutter with a 2:1 block irrespective of whether or not flutter waves are obvious on the ECG. Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. These findings suggest that the causal mechanism associated with rs2200733 is germane to both AF and Afl. Genetic carrier status of rs2200733 failed to predict an increased risk of incident or recurrent AF following catheter ablation for Afl. ConclusionsOur study demonstrates that Afl, whether occurring in isolation or along with AF, is associated with the rs2200733 AF risk allele. Following catheter ablation for Afl, carrier status of rs2200733 failed to predict an increased risk of AF either among all subjects (adjusted HR: 0.94 95% CI: 0.58-1.53, P = 0.806) or among those with isolated Afl (adjusted HR: 1.29 95% CI: 0.51-3.26, P = 0.585). The rs2200733 rare allele was associated with an adjusted 2.06-fold increased odds of isolated Afl (95% CI: 1.13-3.76, P = 0.019) and an adjusted 2.79-fold increased odds of a combined phenotype of AF and Afl (95% CI: 1.81-4.28, P < 0.001). The variant was then assessed as a predictor of incident AF after cavotricuspid isthmus ablation in 87 consecutive typical Afl patients with Cox proportional hazards models. ![]() Methods and resultsWe performed a genetic association study of 295 patients with Afl and/or AF and 469 controls using multivariable logistic regression. We sought to characterize the association between rs2200733 and prevalent Afl and to determine if the variant could predict AF after cavotricuspid isthmus ablation. A single nucleotide polymorphism, rs2200733, is strongly associated with AF. ![]() BackgroundThe prediction of atrial fibrillation (AF) following catheter ablation of atrial flutter (Afl) would be helpful to facilitate targeted arrhythmia monitoring and anti-coagulation strategies. ![]()
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